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A 3D bioprinted model of the renal proximal tubulointerstitial interface for evaluation of drug-induced toxicity

Shelby M. King, Senior Research Scientist, Organovo

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Publication Summary:

Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule (PT) is a primary site of nephrotoxicity, a leading cause of attrition in the drug development pipeline. Current preclinical methods using 2D cell cultures and animal models are unable to fully recapitulate clinical drug responses due to limited in vitro functional lifespan, or species-specific differences. Our NovoGen Bioprinter® Technology offers an opportunity to build in vitro tissue models to enable more accurate prediction of clinical outcomes.

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