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A 3D bioprinted model of the renal proximal tubule for evaluation of drug-induced nephrotoxicity

European Societies of Toxicology

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Publication Summary:

The kidney proximal tubule (PT) is a primary site of nephrotoxicity and resulting drug attrition in the development pipeline. Using Organovo’s proprietary bioprinting platform, we have developed a fully-human in vitro model of the PT to potentially enable more accurate prediction of tissue-level clinical outcomes. ExVive™ Human Kidney Tissue is created in a standard 24-well Transwell® plate by spatially-controlled deposition of cell aggregates in the absence of exogenous scaffold. Tissues are composed of an interstitial layer of renal fibroblasts and endothelial cells supporting a monolayer of human primary PT epithelial cells.

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