Publications

Grounded in a portfolio of in-licensed technologies from the University of Missouri and Clemson University, Organovo’s bioprinting technology has fostered the development of a wide variety of applications. The following selected publications highlight the capabilities of the bioprinting platform:

WEBINARS

Modeling Compound-Induced Fibrogenesis In Vitro Using 3D Bioprinted Human Liver Tissues

Presented by Leah Norona, Doctoral Candidate at UNC Chapel Hill July 2016.

Use of Bioprinted 3D Human Tissues for the Assessment of Drug Toxicity

Presented by Sharon Presnell, Ph.D., Chief Scientific Officer, Organovo June 2016.

IN VITRO TISSUE MODELS

Bioprinted Human Tissues for Toxicology and Disease Modeling

DOWNLOAD POSTERLiver, Presented at Eurotox, Seville, Spain, September 2016.

Modeling Compound-induced Fibrogenesis In Vitro Using Three-dimensional Bioprinted Human Liver Tissues

Leah M. Norona, Deborah G. Nguyen, David A. Gerber, Sharon C. Presnell and Edward L. LeCluyse. Toxicological Sciences doi: 10.1093/toxsci/kfw169 (2016).

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

Deborah G. Nguyen, Juergen Funk, Justin B. Robbins, Candace Crogan-Grundy, Sharon C. Presnell, Thomas Singer, and Adrian B. Roth. PLoS One 11(7): e0158674 (2016).

Modeling Drug-Induced Hepatic Fibrosis In Vitro Using Three-Dimensional Liver Tissue Constructs

DOWNLOAD POSTERLiver, Presented at the World Preclinical Congress, Boston, MA, June 2016.

Bioprinted Human Tissues for Toxicology and Disease Modeling

DOWNLOAD POSTERLiver, Presented at the World Preclinical Congress, Boston, MA, June 2016.

Modeling Drug-Induced Hepatic Fibrosis In Vitro Using Three-Dimensional Liver Tissue Constructs

DOWNLOAD POSTERLiver, Presented at the Society of Toxicology Meeting, New Orleans, LA, March 2016.

Utilization of exVive3D™ Human Liver Tissues for the Evaluation of Valproic Acid-Induced Liver Injury

DOWNLOAD POSTERLiver, Presented at the Society of Toxicology Meeting, New Orleans, LA, March 2016.

Inflammatory Response of Kupffer Cells in 3D Bioprinted Human Liver Tissues

DOWNLOAD POSTERLiver, Presented at the Society of Toxicology Meeting, New Orleans, LA, March 2016.

Monocrotaline Toxicity in 3D-Bioprinted Human Liver Tissue

DOWNLOAD POSTERLiver, Presented at the Society of Toxicology Meeting, New Orleans, LA, March 2016.

Design and characterization of a multicellular, three-dimensional (3D) tissue model of the human kidney proximal tubule

DOWNLOAD POSTERKidney, Presented at the American Society of Experimental Biology, Boston, MA, March 2015.

Three-dimensional (3D) bone tissues derived from stem cells as a novel model for mineralization

DOWNLOAD POSTERBone, Presented at the Stem Cell Meeting on the Mesa, La Jolla, CA, October 2014.

Development of 3D bioprinted human breast cancer for in vitro screening of therapeutics targeted against cancer progression

DOWNLOAD POSTERBreast Cancer, Presented at the American Society of Biology, New Orleans, LA, December 2013.

Bioprinted three dimensional human liver contructs provide a model for interrogating liver biology

DOWNLOAD POSTERLiver, Presented at the American Society of Biology, New Orleans, LA, December 2013.

A novel in vitro three-dimensional bioprinted liver tissue system for drug development

DOWNLOAD POSTERLiver, Presented at the American Society of Experimental Biology, Boston, MA, April 2013.

WHITE PAPERS

The Importance of Multicellularity in Liver Homeostasis and Injury

General – Liver Example

PLATFORM TECHNOLOGY

3D Cell Bioprinting for Regenerative Medicine Research and Therapies

Chirag Khatiwala, Richard Law, Benjamin Shepherd, Scott Dorfman and Marie Csete Gene Therapy and Regulation. Vol. 7, No. 1, 1–19 (2012).

Toward engineering functional organ modules by additive manufacturing

Francoise Marga, Karoly Jakab, Chirag Khatiwala, Benjamin Shepherd, Scott Dorfman, Bradley Hubbard, Stephen Colbert and Gabor Forgacs Biofabrication. 4 022001 (12pp) (2012).

Bioprinting by Continuous Deposition

Presented at the Annual Meeting of the TERMIS-NA, Houston, TX, December 2011.

Scaffold Free NovoGenT Bioprinting Using Various Hydrogels

Presented at the Annual Meeting of the TERMIS-NA, Orlando, FL, December 2010.

Tissue engineering by self-assembly and bio-printing of living cells

Karoly Jakab, Cyrille Norotte, Francoise Marga, Keith Murphy, Gordana Vunjak-Novakovic and Gabor Forgacs Biofabrication. 2, 1–14 (2010).

NovoGenT Bioprinting: Printing 3D Cellular Aggregates

Presented at the Annual Meeting of the TERMIS-NA, Orlando, FL, December 2010.

Scaffold-free vascular tissue engineering using bioprinting

Cyrille Norotte, Francoise S. Marga, Laura E. Niklason, Gabor Forgacs Biomaterials. 30, 5910–5917 (2009).

Tissue engineering by self-assembly of cells printed into topologically defined structures

Karoly Jakab, Cyrille Norotte, Brook Damon, Francoise Marga, Adrian Neagu, Cynthia L. Besch-Williford, Anatoly Kachurin, Kenneth H. Church, Hyoungshin Park, Vladimir Mironov, Roger Markwald, Gordana Vunjak-Novakovic and Gabor Forgacs Tissue Engineering. 14, 413-421 (2008).

Bioprinting living structures

Mironov, V., Prestwich, G. and Forgacs, G. J. Mat. Chem. 17, 2054–2060 (2007).

Before programs: The physical origination of multicellular forms

Stuart A. Newman, Gabor Forgacs and Gerd B. Müller Int. J. Dev. Biol. 50, 289-299 (2006).

Three-dimensional tissue constructs built by bioprinting

K. Jakab, B. Damon, A. Neagu, A. Kachurin and G. Forgacs Biorheology. 43, 509-513 (2006).

Role of physical mechanisms in biological self organization

A. Neagu, K. Jakab, R. Jamison and G. Forgacs Phys. Rev. Lett. 95, 178104 (2005).

Organ printing: fiction or science

K. Jakab, A. Neagu and G. Forgacs Biorheology. 41, 371-375 (2004).

Engineering biological structures of prescribed shape using self-assembling multicellular systems

K. Jakab, A. Neagu, V. Mironov, R.R. Markwald and G. Forgacs Proc. Natl. Acad. Sci. USA. 101, 2864-2869 (2004).

CompuCell, a multi-model framework for simulation of morphogenesis

J.A Izaguirre, R. Chaturvedi, C. Huang, T. Cickovski, P. Virtue, G. Thomas, G. Forgacs, M. Alber, G. Hentschel, S.A. Newman, and J.A. Glazier Bioinformatics. 20, 1129-1137 (2004).

Biological implications of tissue viscoelasticity

G. Forgacs and R. Foty In Function and regulation of cellular systems: experiments and models. Eds. A. Deutsch, M. Falcke, J. Howard and W. Zimmermann. Birkhauser, Basel. 269-277 (2004).

Organ printing: self-assembling cell aggregates as a “bioink”

V. Mironov, R.R. Markwald and G. Forgacs Science and Medicine. 9, 69-71 (2003).

Mechanotransduction through the cytoskeleton

Y. Shafrir and G. Forgacs American Journal of Physiology. 282, 479-486 (2002).

Fusion of cell aggregates: a mathematical model

A. Neagu and G. Forgacs Biomedical Engineering: Recent Developments. J. Vossoughi (Editor). 241-242 (2002).